For doctors
Clinical data
MORE THAN
16,000,000
NIPT TESTS PERFORMED
Up to this date, more than 16,000,000 NIPT tests with our technology have been performed worldwide (more than any other NIPT provider), which means that we offer a proven and trusted service.
VALIDATED ON
147,000
PREGNANCIES
The NIPT by GenePlanet test was independently validated. The largest study of the clinical use of NIPT included more than 147,000 pregnancies.
Below we present data from selected studies. You can find more information at the bottom of the page, in the Published reports section. It lists some of the 31 papers published relating to NIPT.
Non-invasive prenatal testing for trisomy 21, 18, and 13 – clinical experience from 146,958 pregnancies
Wei Wang et al., Journal of Ultrasound in Obstetrics and Gynecology
Total number of samples with a known outcome of pregnancy in 146,958 cases
Swipe horizontaly to reveal more | Trisomy | Trisomy | Trisomy | Trisomies | ||
|---|---|---|---|---|---|---|
Trisomy | T21 | T18 | T13 | Total | ||
True-positive result | 720 | 167 | 22 | 909 | ||
False-positive result | 61 | 51 | 45 | 157 | ||
Detection rate | 99.17% | 98.24% | 100% | 99.02% | ||
Specificity | 99.95% | 99.95% | 99.96% | 99.86% | ||
Positive predictive value (PPV) | 92.19% | 76.61% | 32.84% | 85.27% | ||
Negative predictive value (NPV) | 99.99% | 100% | 100% | 99.99% | ||
The samples were collected between January 2011 and August 2013. The study was published in the scientific journal „Ultrasound in Obstetrics and Gynecology.“
Non-invasive prenatal testing for fetal chromosomal abnormalities: review of 1,982 consecutive cases in a single centre
Lau T. K. et al, ‘Non-invasive prenatal testing for fetal chromosomal abnormalities by low-coverage whole-genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center’, Ultrasound Obstet Gynecol 2014; 43: 254–264
Swipe horizontaly to reveal more | High risk | High risk | High risk | High risk | ||
|---|---|---|---|---|---|---|
Tested samples | 23 | 4 | 2 | 1982 | ||
Karyotyping | 23 | 4 | 2 | 29 | ||
Follow-up investigation | 0 | 0 | 0 | 1645 | ||
Detection rate | 100% | 100% | 100% | - | ||
Specificity | 100% | 100% | 100% | - | ||
False-positive rate | 0% | 0% | 0% | - | ||
False-negative rate | 0% | 0% | 0% | - | ||
Large scale validation of the NIPT test: for trisomies 21 and 18 in 11,105 pregnancies
Dan S. et al, ‘Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors.’ Prenat. Diagn., 32: 1225–1232. doi: 10.1002/pd.4002
Swipe horizontaly to reveal more | Positive results | Positive results | Positive results | Negative results | Positive results | Negative results | |||
|---|---|---|---|---|---|---|---|---|---|
NIPT positive | |||||||||